Although My 600-Lb Life can be heartbreaking at times, there are several inspirational weight loss journeys from the series that still resonate with fans today. Viewers are in awe of the dramatic number of pounds shed by the cast members, and some of the show’s stars have lost more than 500 lbs. There are several people from the series who left lasting impressions on fans, thanks to their resilience during incredibly difficult weight loss processes.

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My 600-Lb Life first aired in 2012 on TLC, and a decade later, the series continues to resonate with fans, thanks to unforgettable body makeovers. With over one hundred cast members chronicling their starting weights, and year-long fights to lose the pounds, there are many fan-favorites. The show also features a surgeon, Dr. Younan Nowzaradan (also known as Dr. Now), who is there to help each cast member on their journey.

The show lifts the veil on morbid obesity, as well as some individual causes of it, including childhood trauma. While some cast members are reluctant to put in the work to lose the weight, others are eager to do so. Three cast members stand out for their winning personalities on My 600-Lb Life, as well as their body transformations.

Milla Clark

When Milla Clark first appeared on My 600-Lb Life in season 4, she weighed over 700 lbs. She was married with five kids, but had been confined to her bed, barely able to walk for over a decade. Things were even more difficult for her when her husband tragically passed away during filming. However, this motivated Milla to lose enough weight to qualify for surgery. Her backstory and positivity during the process made her a fan-favorite. She also became one the biggest success stories in the franchise, as she lost over 500 lbs.

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Christina Phillips

Christina is another inspirational cast member from My 600-Lb Life season 2, weighing just over 700 lbs. She appeared on the show at age 22, and hadn’t left her house in over two years due to her weight. Christina had struggled with her weight since childhood, and felt trapped and hopeless at the start of the show. Her commitment to losing weight (also over 500 lbs.) was an inspiration to fans. Christina has continued working out and eating a healthy diet, so she can focus on raising her son.

Chuck Turner

My 600-Lb Lifeseason two featured a variety of memorable stars, including Chuck Turner, who is another lovable cast member. He weighed nearly 700 lbs. at the start of filming, and unlike many other stars who had struggled with their weights since childhood, Chuck’s weight gain happened later in life. He overate to cope with his first wife passing away. The Texas native lost over 400 lbs, and is living his best life in his revamped body. Chuck’s ability to overcome tragedy, and learn to love himself again, made for impactful My600 Lb Life episodes.