Following a shocking cliffhanger in season 1, Grey’s Anatomy season 2 was a rollercoaster of emotions from start to finish. Derek and Meredith’s romance hangs in the balance after Addison comes into the picture, Burke and Cristina clarify their own relationship status, and a tragic love story blooms between Izzie Stevens and Denny Duquette.

The intensely emotional themes of season 2 of the popular medical drama make for incredible quotes that range from heartfelt to heartbreaking. Season 1 may have set the stage, but some of the best lines in season 2 hone in on not only the romantic relationships but the development of lifelong bonds of friendship.

10 “You Were Like Coming Up For Fresh Air. It Was Like I Was Drowning And You Saved Me”

Hurt and confused after finding out that Derek has been married this whole time, Meredith confronts him. She needs to know if she was some fling, or if she truly meant anything to him. There is no argument that Derek is in the wrong for his lack of honesty, but his response to her is nothing but pure and sincere, and it strikes a chord in Meredith, even if she isn’t ready to admit it.

9 “You’re My Person”

“You’re my person.” These three, little words have become a defining phrase in Cristina and Meredith’s friendship, and they are said for the first time in the season 2 premiere. Needing someone as her emergency contact before she can confirm her appointment to get an abortion, Cristina begrudgingly lets Meredith know that she is the only one that she trusts with this. She is her person.

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8 “It’s Not Hard. It’s Painful, But It’s Not Hard. You Know What To Do Already. If You Didn’t You Wouldn’t Be In So Much Pain”

Dr. Bailey doesn’t coddle her interns, but that doesn’t mean that she doesn’t care about them. If she must be involved in their personal lives, she will be there with firm but fair pearls of wisdom when her colleagues need her most.

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When Meredith is feeling lost about her relationship with Derek, Bailey gives her the nudge she needs, which leads to one of the most memorable confessions of love in the series.

7 “Life Is Too Damn Short To Follow The Rules”

One of season 2’s prevailing themes is being courageous enough to take a chance on love. There is no better example of that than ailing heart patient, Denny Duquette. Being on the brink of death and pesky hospital rules can’t stop him from pursuing the love of his life. Even when Meredith gently warns him that it isn’t a good idea, Denny is confident that life is too short to let true love pass him by.

6 “For A Kiss To Be Real, You Got To Want It To Mean Something. And You Want It To Be With Someone You Can’t Get Out Of Your Head”

Alex Karev was often a problematic character who often did some unsavory things. That makes this particular moment a surprising and meaningful turning point for the arrogant intern.

A patient wants to give him her first kiss, and for once, he doesn’t make a selfish decision. He decides not to kiss her and says she should save her first kiss for someone she cares for. It’s a rare show of humanity and a reminder that Alex may be flawed, but he does care about his patients.

5 “So, Pick Me. Choose Me. Love Me”

Meredith finally makes her choice about what she wants and tells Derek in a bold and impassioned declaration of love. She embraces her feelings, gathers her courage, and tells him that it would tear her apart for him not to choose to be with her. She is exhausted from running from intimacy and pretending that she doesn’t want him. He can take it or leave it, but she needed to say it.

4 “If You Want Crappy Things To Stop Happening To You, Then Stop Accepting Crap And Demand Something More”

Cristina is always reliable when it comes to doling out confident and blunt advice. Feeling heartsick over his night with Meredith, and sorry for himself about embarrassing himself in front of the other interns, George is in a funk and Cristina has had enough.

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There is a time to demand respect, or just step away from the situation altogether. It’s a hard lesson to learn, but it’s a necessary one for them all.

3 “I Choose You, Izzie Stevens”

Choosing love is an enduring theme for all the main characters this season, but especially with Izzie Stevens. Struggling between her physical relationship with Alex, and the genuine feelings that she has for Denny, it’s hard for her to believe that someone would want her so fully and selflessly. Denny doesn’t hesitate to let her know in every way that he knows how. She is and always will be his choice.

2 “All I Could Think About Was I’m Going To Die Today And I Can’t Remember Our Last Kiss”

Seattle Grace Hospital is in Code Black, lives hang in the balance, and Bailey is in labor in one of the most dramatic episodes of the season. Meredith spends hours with her hand trapped in a body, unaware if she is going to survive the night, and all she can think of is Derek. Once the panic fades, he is the first person she finds. She may not remember their last kiss, but he does, and he is happy to tell her every, romantic detail.

1 “I Cut The L-VAD Wire”

Izzie admits to cutting Denny’s L-VAD wire, and in a scene that is straight out of Spartacus, Meredith, George, and Cristina step forward to shoulder the blame. It doesn’t matter that the truth is obvious. This is about loyalty and showing support for their friend. Though Izzie does quit for a time after Denny’s tragic passing, this moment proves that they have become so much more than simply coworkers.

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